Activation of M1 mAChRs by lesatropane rescues glutamate neurotoxicity in PC12 cells via PKC-mediated phosphorylation of ERK1/2

Lesatropane, a synthesized chiral tropane (3S, 6S-isomer of satropane), is a novel muscarinic agonist, and is being under preclinical development in China for the treatment of primary glaucoma. The reports concerning that activation of muscarinic acetylcholine receptors (mAChRs) could protect cells...

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Hlavní autoři:	Ke Ma, Zhi-Hui Yang, Li-Min Yang, Hong-Zhuan Chen, Yang Lu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2013-08-01
Edice:	Biomolecules & Biomedicine
Témata:	muscarinic agonist neuroprotective effects glutamate PC12 cells
On-line přístup:	https://www.bjbms.org/ojs/index.php/bjbms/article/view/2346
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