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Activation of M1 mAChRs by lesatropane rescues glutamate neurotoxicity in PC12 cells via PKC-mediated phosphorylation of ERK1/2

Lesatropane, a synthesized chiral tropane (3S, 6S-isomer of satropane), is a novel muscarinic agonist, and is being under preclinical development in China for the treatment of primary glaucoma. The reports concerning that activation of muscarinic acetylcholine receptors (mAChRs) could protect cells...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ke Ma, Zhi-Hui Yang, Li-Min Yang, Hong-Zhuan Chen, Yang Lu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2013-08-01
Cyfres:Biomolecules & Biomedicine
Pynciau:
Mynediad Ar-lein:https://www.bjbms.org/ojs/index.php/bjbms/article/view/2346
Tagiau: Ychwanegu Tag
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