Dimethyloxalylglycine Suppresses SREBP1c and Lipogenic Gene Expressions in Hepatocytes Independently of HIF1A

Dimethyloxalylglycine (DMOG) is a representative inhibitor of the prolyl hydroxylase domain (PHD), which mediates the degradation of hypoxia-inducible factor-1-alpha (HIF1A). DMOG exerts its pharmacological effects via the canonical pathway that involves PHD inhibition; however, it remains unclear w...

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Detalhes bibliográficos

Principais autores:	Yong Seong Kwon, Ye Eun Cho, Yeonsoo Kim, Minseob Koh, Seonghwan Hwang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-03-01
Colecção:	Current Issues in Molecular Biology
Assuntos:	dimethyloxalylglycine prolyl hydroxylase domain hypoxia-inducible factor-1-alpha fatty liver fatty acid synthesis sterol regulatory element-binding protein-1c
Acesso em linha:	https://www.mdpi.com/1467-3045/46/3/151
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