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Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα

In the process of seeking sterol regulatory element-binding protein 1a (SREBP-1a) target genes, we identified and cloned a cDNA clone encoding mouse Δ5-desaturase (D5D). The hepatic expression of D5D as well as Δ6-desaturase (D6D) was highly activated in transgenic mice overexpressing nuclear SREBP-...

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Principais autores: Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi, Michiyo Amemiya-Kudo, Tomohiro Yoshikawa, Alyssa H. Hasty, Yoshiaki Tamura, Jun-ichi Osuga, Hiroaki Okazaki, Yoko Iizuka, Akimitsu Takahashi, Hirohito Sone, Takanari Gotoda, Shun Ishibashi, Nobuhiro Yamada
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2002-01-01
Serier:Journal of Lipid Research
Fag:
lipogenesis
nutrition
polyunsaturated fatty acids
sterol regulatory element-binding protein
Online adgang:http://www.sciencedirect.com/science/article/pii/S0022227520301930
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