Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice

Wnt/β-catenin is involved in every aspect of embryonic development and in the pathogenesis of many human diseases, and is also implicated in organ fibrosis. However, the role of β-catenin-mediated signaling on liver fibrosis remains unclear. To explore this issue, the effects of PRI-724, a selective...

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Bibliografische Detailangaben

Hauptverfasser:	Yosuke Osawa, Keisuke Oboki, Jun Imamura, Ekumi Kojika, Yukiko Hayashi, Tsunekazu Hishima, Toshiji Saibara, Futoshi Shibasaki, Michinori Kohara, Kiminori Kimura
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2015-11-01
Schriftenreihe:	EBioMedicine
Schlagworte:	Liver Fibrosis Beta-catenin Hepatic stellate cell Macrophage***
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2352396415301742
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