Urea transporter evolution: deep conservation, recent adaptation in mammals, and maintenance of the Jka/Jkb polymorphism in the past ~ 110,000 years

Abstract Urea is a central metabolite and many organisms encode membrane integral urea transporters (UTs). Here, we combined motif homology searches, phylogenetics, and molecular evolution with paleogenomics to investigate the evolutionary dynamics of UTs from prokaryotes to human populations. We di...

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Hlavní autoři:	Rachele Cagliani, Uberto Pozzoli, Diego Forni, Alessandra Mozzi, Manuela Sironi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-02-01
Edice:	Biology Direct
Témata:	Urea transporters Positive selection Kidd blood group SLC14A1 Asp280Asn variant Balancing selection
On-line přístup:	https://doi.org/10.1186/s13062-026-00741-3
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