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Transcriptional activity regulates alternative cleavage and polyadenylation

Abstract Genes containing multiple pre‐mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3′ untranslated regions (UTRs). By systematic analysis of human and mouse transcriptomes, we found that short 3′UTR isoforms are relatively more abundant when genes are...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Zhe Ji, Wenting Luo, Wencheng Li, Mainul Hoque, Zhenhua Pan, Yun Zhao, Bin Tian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Nature 2011-09-01
Schriftenreihe:Molecular Systems Biology
Schlagworte:
3′ end processing
3′UTR
alternative polyadenylation
post‐transcriptional control
transcription
Online-Zugang:https://doi.org/10.1038/msb.2011.69
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