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Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease

Abstract Background E-cadherin, a major actor of cell adhesion in the intestinal barrier, is encoded by the CDH1 gene associated with susceptibility to Crohn Disease (CD) and colorectal cancer. Since epigenetic mechanisms are suspected to contribute to the multifactorial pathogenesis of CD, we studi...

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Bibliografiset tiedot
Päätekijät: Charles de Ponthaud, Solafah Abdalla, Marie-Pierre Belot, Xiaojian Shao, Christophe Penna, Antoine Brouquet, Pierre Bougnères
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMC 2024-02-01
Sarja:Clinical Epigenetics
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Linkit:https://doi.org/10.1186/s13148-024-01631-z
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