Broad-Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available, Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside (GS-441524)

ABSTRACT The necessity for intravenous administration of remdesivir confines its utility for treatment of coronavirus disease 2019 (COVID-19) to hospitalized patients. We evaluated the broad-spectrum antiviral activity of ODBG-P-RVn, an orally available, lipid-modified monophosphate prodrug of the r...

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Egile Nagusiak:	Michael K. Lo, Punya Shrivastava-Ranjan, Payel Chatterjee, Mike Flint, James R. Beadle, Nadejda Valiaeva, Joyce Murphy, Robert T. Schooley, Karl Y. Hostetler, Joel M. Montgomery, Christina F. Spiropoulou
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology 2021-12-01
Saila:	Microbiology Spectrum
Gaiak:	SARS-CoV-2 Ebola virus Nipah virus respiratory viruses hemorrhagic fever virus filovirus
Sarrera elektronikoa:	https://journals.asm.org/doi/10.1128/Spectrum.01537-21
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