Metabolism and Bioactivation of Corynoline With Characterization of the Glutathione/Cysteine Conjugate and Evaluation of Its Hepatotoxicity in Mice

Corynoline (CRL), an isoquinoline alkaloid, is the major constituent derived from Corydalis bungeana Herba, which is a well-known Chinese herbal medicine widely used in many prescriptions. The purpose of this study was to comprehensively investigate the metabolism and bioactivation of CRL, and ident...

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Principais autores:	Ruijuan Liu, Fang Zhou, He He, Jingyao Wei, Xin Tian, Li Ding
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-11-01
coleção:	Frontiers in Pharmacology
Assuntos:	corynoline metabolism bioactivation CYP450 enzymes hepatotoxicity mass spectrometry
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphar.2018.01264/full
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