Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway

Catalpol significantly reduces triptolide-induced hepatotoxicity, which is closely related to autophagy. The aim of this study was to explore the unclear protective mechanism of catalpol against triptolide. The detoxification effect of catalpol on triptolide was investigated in HepaRG cell line. The...

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Bibliografski detalji

Glavni autori:	Linluo Zhang, Changqing Li, Ling Fu, Zhichao Yu, Gengrui Xu, Jie Zhou, Meiyu Shen, Zhe Feng, Huaxu Zhu, Tong Xie, Lingling Zhou, Xueping Zhou
Format:	Artigo
Jezik:	Inglês
Izdano:	PeerJ Inc. 2022-01-01
Serija:	PeerJ
Teme:	Hepatotoxicity Autophagy ERS Triptolide PERK Catalpol
Online pristup:	https://peerj.com/articles/12759.pdf
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