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CYP450s-Activity Relations of Celastrol to Interact with Triptolide Reveal the Reasons of Hepatotoxicity of <i>Tripterygium wilfordii</i>

Celastrol and triptolide, as the two main bio-activity ingredients in <i>Tripterygium wilfordii,</i> have wide anticancer pharmacological potency, as well as anti-inflammatory and immunosuppression effects. However, they have potential hepatotoxicity and underlying mechanisms of them-induced toxicit...

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Principais autores: Chunhuan Jin, Zijun Wu, Lili Wang, Yoshikatsu Kanai, Xin He
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2019-06-01
Serier:Molecules
Fag:
celastrol
triptolide
CYP450 enzymes
hepatotoxicity
drug-drug interaction (DDI)
Online adgang:https://www.mdpi.com/1420-3049/24/11/2162
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