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TDP-43 promotes efficient HSV-1 replication in human DRG-derived neurons

ABSTRACT TAR DNA-binding protein 43 (TDP-43) is a versatile nuclear RNA-binding protein that performs important functions in RNA localization, processing, and stability. In the neurodegenerative disease amyotrophic lateral sclerosis (ALS) TDP-43 forms toxic, insoluble cytoplasmic aggregates that ult...

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Principais autores: Shirley E. Braspenning, Denise Ohnezeit, Olivia A. DeGulis, Angus C. Wilson, Ian J. Mohr
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2025-12-01
Serier:Journal of Virology
Fag:
HSV-1
sensory neurons
TAR DNA-binding protein 43
direct RNA-sequencing
RNA splicing
Online adgang:https://journals.asm.org/doi/10.1128/jvi.00915-25
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