Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies

TAR DNA-binding protein 43 (TDP-43) is a major component of ubiquitin-positive inclusion of TDP-43 proteinopathies including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitinated inclusions, which is now referred to as FTLD-TDP. TDP-43 in the aberrant inclusion is kn...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Yohei Iguchi, Masahisa Katsuno, Shinnosuke Takagi, Shinsuke Ishigaki, Jun-ichi Niwa, Masato Hasegawa, Fumiaki Tanaka, Gen Sobue
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2012-03-01
Sarja:	Neurobiology of Disease
Aiheet:	TAR DNA-binding protein 43 kDa (TDP-43) TDP-43 proteinopathy Oxidative stress Glutathione depletion Post-translational modification Protein phosphorylation
Linkit:	http://www.sciencedirect.com/science/article/pii/S0969996111003779
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