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Disruption of Mitochondrion-To-Nucleus Interaction in Deceased Cloned Piglets.

Most animals produced by somatic cell nuclear transfer (SCNT) are heteroplasmic for mitochondrial DNA (mtDNA). Oxidative phosphorylation (OXPHOS) in clones therefore requires the coordinated expression of genes encoded by the nuclear DNA and the two sources of mitochondria. Such interaction is rarel...

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Autori principali: Joonghoon Park, Liangxue Lai, Melissa S Samuel, David Wax, Randall S Prather, Xiuchun Tian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2015-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC4466210?pdf=render
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