Production of α-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations

Hyperacute rejection of porcine organs by old world primate recipients is mediated through preformed antibodies against galactosyl-α-1,3-galactose (Galα-1,3-Gal) epitopes expressed on the pig cell surface. Previously, we generated inbred miniature swine with a null allele of the α-1,3-galactosyltran...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Kolber-Simonds, Donna, Lai, Liangxue, Watt, Steven R., Denaro, Maria, Arn, Scott, Augenstein, Monica L., Betthauser, Jeffery, Carter, David B., Greenstein, Julia L., Hao, Yanhong, Im, Gi-Sun, Liu, Zhonghua, Mell, Greg D., Murphy, Clifton N., Park, Kwang-Wook, Rieke, August, Ryan, David J. J., Sachs, David H., Forsberg, Erik J., Prather, Randall S., Hawley, Robert J.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2004
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409919/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15123792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307819101
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