Production of α-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations

Hyperacute rejection of porcine organs by old world primate recipients is mediated through preformed antibodies against galactosyl-α-1,3-galactose (Galα-1,3-Gal) epitopes expressed on the pig cell surface. Previously, we generated inbred miniature swine with a null allele of the α-1,3-galactosyltran...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kolber-Simonds, Donna, Lai, Liangxue, Watt, Steven R., Denaro, Maria, Arn, Scott, Augenstein, Monica L., Betthauser, Jeffery, Carter, David B., Greenstein, Julia L., Hao, Yanhong, Im, Gi-Sun, Liu, Zhonghua, Mell, Greg D., Murphy, Clifton N., Park, Kwang-Wook, Rieke, August, Ryan, David J. J., Sachs, David H., Forsberg, Erik J., Prather, Randall S., Hawley, Robert J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2004
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409919/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15123792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307819101
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