Protein neddylation in lung tumorigenesis: Target validation and targeted therapy
Much akin to ubiquitylation, neddylation is catalyzed by a cascade of three enzymes: E1 NEDD8-activating enzyme, E2 NEDD8-conjugating enzyme (UBE2M or UBE2F), and E3 NEDD8 ligases. The best-known neddylation substrates are the members of cullin family, leading to the activation of Cullin-RING ligase...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
KeAi Communications Co. Ltd.
2025-09-01
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| Serie: | Fundamental Research |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S2667325823002856 |
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