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Protein neddylation in lung tumorigenesis: Target validation and targeted therapy

Much akin to ubiquitylation, neddylation is catalyzed by a cascade of three enzymes: E1 NEDD8-activating enzyme, E2 NEDD8-conjugating enzyme (UBE2M or UBE2F), and E3 NEDD8 ligases. The best-known neddylation substrates are the members of cullin family, leading to the activation of Cullin-RING ligase...

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Principais autores: Yawen Zheng, Hiroyuki Inuzuka, Wenyi Wei, Yi Sun
Format: Artigo
Sprog:Inglês
Udgivet: KeAi Communications Co. Ltd. 2025-09-01
Serier:Fundamental Research
Fag:
Cullin-RING ligases
Inflammatory responses
Lung tumorigenesis
Neddylation
Small molecule inhibitors
Tumor microenvironment
Online adgang:http://www.sciencedirect.com/science/article/pii/S2667325823002856
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