Proteolysis targeting chimera degraders target pseudokinases to treat metabolic dysfunction-associated steatohepatitis and fibrosis: Mechanisms and therapeutic insights

Metabolic dysfunction-associated steatohepatitis (MASH, previously NASH) is the severe type of metabolic dysfunction-associated steatotic liver disease (MASLD, previously NAFLD), the most common liver condition. The excessive hepatic lipid accumulation triggers apoptosis of hepatocytes and lobular i...

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Hlavní autoři:	Yibing Wang, Jiajing Peng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-12-01
Edice:	Pharmacological Research
Témata:	Pseudokinases PROTAC MASH Liver fibrosis Inflammation Therapeutics
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1043661825004797
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