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Proteolysis targeting chimera degraders target pseudokinases to treat metabolic dysfunction-associated steatohepatitis and fibrosis: Mechanisms and therapeutic insights

Metabolic dysfunction-associated steatohepatitis (MASH, previously NASH) is the severe type of metabolic dysfunction-associated steatotic liver disease (MASLD, previously NAFLD), the most common liver condition. The excessive hepatic lipid accumulation triggers apoptosis of hepatocytes and lobular i...

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Principais autores: Yibing Wang, Jiajing Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-12-01
coleção:Pharmacological Research
Assuntos:
Pseudokinases
PROTAC
MASH
Liver fibrosis
Inflammation
Therapeutics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1043661825004797
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