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The WASH-complex subunit Strumpellin regulates integrin αIIbβ3 trafficking in murine platelets

Abstract The platelet specific integrin αIIbβ3 mediates platelet adhesion, aggregation and plays a central role in thrombosis and hemostasis. In resting platelets, αIIbβ3 is expressed on the membrane surface and in intracellular compartments. Upon activation, the number of surface-expressed αIIbβ3 i...

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Principais autores: Yvonne Schurr, Lucy Reil, Markus Spindler, Bernhard Nieswandt, Laura M. Machesky, Markus Bender
格式: Artigo
語言:Inglês
出版: Nature Portfolio 2023-06-01
叢編:Scientific Reports
在線閱讀:https://doi.org/10.1038/s41598-023-36387-8
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