RIF1 regulates early replication timing in murine B cells

Abstract The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermuta...

Полное описание

Библиографические подробности

Главные авторы:	Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N. Klein, Mariia Nazarova, Ursula E. Schoeberl, David M. Gilbert, Sara C. B. Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2023-12-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-023-43778-y
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