RIF1 regulates early replication timing in murine B cells

Abstract The mammalian DNA replication timing (RT) program is crucial for the proper functioning and integrity of the genome. The best-known mechanism for controlling RT is the suppression of late origins of replication in heterochromatin by RIF1. Here, we report that in antigen-activated, hypermuta...

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Bibliographic Details

Main Authors:	Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N. Klein, Mariia Nazarova, Ursula E. Schoeberl, David M. Gilbert, Sara C. B. Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri
Format:	Artigo
Language:	Inglês
Published:	Nature Portfolio 2023-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-43778-y
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