High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

Abstract Rare coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer's disease (AD), but how they confer this risk remains uncertain. We assessed binding of TREM2, AD‐associated TREM2 variants to various forms of Aβ and APOE i...

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Podrobná bibliografie

Hlavní autoři:	Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz, Yong Ran, Thomas E Mahan, Paramita Chakrabaty, David M Holtzman, Jason D Ulrich, Marco Colonna, Todd E Golde
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2018-10-01
Edice:	EMBO Molecular Medicine
Témata:	Alzheimer's disease amyloid APOE innate immune response TREM2
On-line přístup:	https://doi.org/10.15252/emmm.201809027
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