Features of the 8-oxo-7,8-dihydro-2′-dGTP behavior in active site of human DNA polymerase β: structural investigation in silico

The oxidized bases in the composition of DNA as well as DNA precursors (desoxynucleotide triphosphates, dNTPs) appearing in living cell as a result of oxidative stress are the one of major sources of genomic instability. Among oxidized forms of nitrogenous bases, the 8-oxo-7,8-dihydro-2-deoxyguanine...

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Autor principal:	A. Yu. Nyporko
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Львівський національний університет імені Івана Франка 2014-04-01
Colecção:	Біологічні студії
Assuntos:	8-oxo-7 8-dihydro-2′-dgtp 8-oxo-dgtp dna polymerase β mole­cular dynamics structural analysis delayed dissociation
Acesso em linha:	http://publications.lnu.edu.ua/journals/index.php/biology/article/view/151
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