Dexmedetomidine ameliorates hepatic ischemia reperfusion injury via modulating SIRT3 mediated mitochondrial quality control

Abstract Ischaemia-reperfusion (IR) damage is an inevitable adverse effect of liver surgery. Recent research has found that IR damage is involved in severe mitochondrial dysfunction. Mitochondrial biosynthesis and dynamics control mitochondrial mass, distribution, and function. Sirtuin 3 (SIRT3) is...

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主要な著者:	Xiaqing Ning, Jilang Tang, Xueqin Li, Jiaqi Wang, Fan Zhai, Congcong Jiang, Shixia Zhang
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-02-01
シリーズ:	Scientific Reports
主題:	Dexmedetomidine Ischemia-reperfusion Liver Mitochondrial biogenesis Mitochondrial dynamics SIRT3
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-90069-1
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