Dexmedetomidine Alleviates Ischemia/Reperfusion-Associated Acute Kidney Injury by Enhancing Autophagic Activity via the α2-AR/AMPK/mTOR Pathway

Background: Dexmedetomidine (DEX) reportedly protects against ischemia-reperfusion (I/R) injury and associated damage to the kidneys, but the underlying mechanisms have yet to be established. Methods: Unilateral nephrectomy was performed in Wistar rats, and the remaining kidney was clamped for 1 h p...

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Auteurs principaux:	Bi-Ying Zhou, Jing Yang, Rui-Rui Luo, Yan-Lin Sun, Hao-Tian Zhang, Ai-Xiang Yang, Guo-Xing Zhang
Format:	Artigo
Langue:	Inglês
Publié:	IMR Press 2023-12-01
Collection:	Frontiers in Bioscience-Landmark
Sujets:	acute kidney injury renal ischemia and reperfusion dexmedetomidine autophagy α2-ar/ampk/mtor pathway
Accès en ligne:	https://www.imrpress.com/journal/FBL/28/12/10.31083/j.fbl2812323
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