CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners

Summary: Bone marrow (BM) niche cells help to keep adult hematopoietic stem cells (HSCs) in a quiescent state via secreted factors and induction of cell-cycle inhibitors. Here, we demonstrate that the adapter protein CABLES1 is a key regulator of long-term hematopoietic homeostasis during stress and...

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Главные авторы:	Liang He, Florian Beghi, Viviane Baral, Mallorie Dépond, Yanyan Zhang, Virginie Joulin, Bo R. Rueda, Patrick Gonin, Adlen Foudi, Monika Wittner, Fawzia Louache
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2019-08-01
Серии:	Stem Cell Reports
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2213671119302280
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