CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners

Summary: Bone marrow (BM) niche cells help to keep adult hematopoietic stem cells (HSCs) in a quiescent state via secreted factors and induction of cell-cycle inhibitors. Here, we demonstrate that the adapter protein CABLES1 is a key regulator of long-term hematopoietic homeostasis during stress and...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Liang He, Florian Beghi, Viviane Baral, Mallorie Dépond, Yanyan Zhang, Virginie Joulin, Bo R. Rueda, Patrick Gonin, Adlen Foudi, Monika Wittner, Fawzia Louache
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2019-08-01
Serie:	Stem Cell Reports
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2213671119302280
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!