Potential and pitfalls of 89Zr-immuno-PET to assess target status: 89Zr-trastuzumab as an example

Abstract Background 89Zirconium-immuno-positron emission tomography (89Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy. We aim to determine the relation between antibody tumor uptake and target concentration to improve future study design and interpretation. Me...

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Auteurs principaux:	Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt, Josée M. Zijlstra, Otto S. Hoekstra, Ronald Boellaard, Guus A. M. S. van Dongen, Dhaval K. Shah, Yvonne W. S. Jauw
Format:	Artigo
Langue:	Inglês
Publié:	SpringerOpen 2021-08-01
Collection:	EJNMMI Research
Sujets:	89Zr-immuno-PET Modelling Molecular imaging Monoclonal antibody Target expression
Accès en ligne:	https://doi.org/10.1186/s13550-021-00813-7
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