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Depletion of HIF-1α by Inducible Cre/loxP Increases the Sensitivity of Cultured Murine Hepatocytes to Ionizing Radiation in Hypoxia

The transcription factor hypoxia-inducible factor (HIF) is the main oxygen sensor which regulates adaptation to cellular hypoxia. The aim of this study was to establish cultured murine hepatocyte derived cells (mHDC) as an in vitro model and to analyze the role of HIF-1α in apoptosis induction, DNA...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Akram Hamidi, Alexandra Wolf, Rositsa Dueva, Melanie Kaufmann, Kirsten Göpelt, George Iliakis, Eric Metzen
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-05-01
Schriftenreihe:Cells
Schlagworte:
hypoxia
HIF-1α
ionizing radiation
apoptosis
DNA damage repair
Online-Zugang:https://www.mdpi.com/2073-4409/11/10/1671
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