Depletion of HIF-1α by Inducible Cre/loxP Increases the Sensitivity of Cultured Murine Hepatocytes to Ionizing Radiation in Hypoxia

The transcription factor hypoxia-inducible factor (HIF) is the main oxygen sensor which regulates adaptation to cellular hypoxia. The aim of this study was to establish cultured murine hepatocyte derived cells (mHDC) as an in vitro model and to analyze the role of HIF-1α in apoptosis induction, DNA...

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Egile Nagusiak:	Akram Hamidi, Alexandra Wolf, Rositsa Dueva, Melanie Kaufmann, Kirsten Göpelt, George Iliakis, Eric Metzen
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2022-05-01
Saila:	Cells
Gaiak:	hypoxia HIF-1α ionizing radiation apoptosis DNA damage repair
Sarrera elektronikoa:	https://www.mdpi.com/2073-4409/11/10/1671
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