Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health

Dietary restriction (DR) is a universal anti-aging intervention, which reduces age-related nervous system pathologies and neurological decline. The degree to which the neuroprotective effect of DR operates by attenuating cell intrinsic degradative processes rather than influencing non-cell autonomou...

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Principais autores:	María Björk Birkisdóttir, Lisanne J. Van’t Sant, Renata M. C. Brandt, Sander Barnhoorn, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Dick Jaarsma
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-01-01
Colecção:	Frontiers in Aging Neuroscience
Assuntos:	cerebellum DNA repair nucleotide excision repair transcription stress dietary restriction Progeria
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnagi.2022.1095801/full
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