Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo

Mutations in KCNC3, which encodes the Kv3.3 K+ channel, cause spinocerebellar ataxia 13 (SCA13). SCA13 exists in distinct forms with onset in infancy or adulthood. Using zebrafish, we tested the hypothesis that infant- and adult-onset mutations differentially affect the excitability and viability of...

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主要な著者:	Jui-Yi Hsieh, Brittany N Ulrich, Fadi A Issa, Meng-chin A Lin, Brandon Brown, Diane M Papazian
フォーマット:	Artigo
言語:	Inglês
出版事項:	eLife Sciences Publications Ltd 2020-07-01
シリーズ:	eLife
主題:	cerebellum spinocerebellar ataxia Purkinje cell excitability cerebellar development degeneration
オンライン･アクセス:	https://elifesciences.org/articles/57358
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