Phage resistance formation and fitness costs of hypervirulent Klebsiella pneumoniae mediated by K2 capsule-specific phage and the corresponding mechanisms

IntroductionPhage is promising for the treatment of hypervirulent Klebsiella pneumoniae (hvKP) infections. Although phage resistance seems inevitable, we found that there still was optimization space in phage therapy for hvKP infection.MethodsThe clinical isolate K. pneumoniae FK1979 was used to rec...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Miran Tang, Zeyu Huang, Xiaodong Zhang, Jingchun Kong, Beibei Zhou, Yijia Han, Yi Zhang, Lijiang Chen, Tieli Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-07-01
coleção:	Frontiers in Microbiology
Assuntos:	bacteriophage phage resistance hypervirulent Klebsiella pneumoniae capsular polysaccharides lipopolysaccharides polysaccharide depolymerase
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmicb.2023.1156292/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!