Frontotemporal dementia as a consequence of GRN mutations: From disease cause to models to therapies

Frontotemporal dementia (FTD) encompasses a broad, clinically and neuropathologically diverse group of neurodegenerative disorders associated with changes in personality, behaviour, and/or language due to the progressive degeneration of the frontal and temporal lobes of the brain. Mutations in sever...

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Hlavní autoři:	Sara Salzano, Chiara Bertasini, Shima Tavakolian Haghighi, Johan Lundkvist, Lars U. Wahlberg, Cristiano Chiamulera, Gaetano NA Vattemi, Fabrizio Gardoni, Giovanna Paolone
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-11-01
Edice:	Pharmacological Research
Témata:	GRN-FTD PGRN TDP-43 aggregates Gene mutations Preclinical models Therapeutic treatments
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1043661825003822
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