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HHIP Overexpression Suppresses Human Gastric Cancer Progression and Metastasis by Reducing Its CpG Island Methylation

Human hedgehog-interacting protein (HHIP), a negative regulator of hedgehog (HH) signaling pathway, has been reported to be dysregulated in many types of cancer, including gastric cancer. However, the inhibitory role of HHIP as well as the underlying molecular mechanism of HHIP regulation in gastric...

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Principais autores: Yu Song, Jianchen Tu, Yanan Cheng, Fang Zhou, Peilin Liu, Shuangshuang Zhou, Yongjun Gu, Yang Sun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-12-01
coleção:Frontiers in Oncology
Assuntos:
HHIP
hedgehog signaling
gastric cancer
methylation
metastasis
growth
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2020.01667/full
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