Impaired flickering of the permeability transition pore causes SPG7 spastic paraplegia
Background: Mutations of the mitochondrial protein paraplegin cause hereditary spastic paraplegia type 7 (SPG7), a so-far untreatable degenerative disease of the upper motoneuron with still undefined pathomechanism.The intermittent mitochondrial permeability transition pore (mPTP) opening, called fl...
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| Principais autores: | , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2020-11-01
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| Serier: | EBioMedicine |
| Fag: | |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S2352396420304266 |
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