Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia SPAST Patient Neurons

Hereditary spastic paraplegia (HSP) is a group of inherited disorders characterized by progressive spasticity and paralysis of the lower limbs. Autosomal dominant mutations in SPAST gene account for ∼40% of adult-onset patients. We have previously shown that SPAST patient cells have reduced organell...

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Egile Nagusiak:	Gautam Wali, Erandhi Liyanage, Nicholas F. Blair, Ratneswary Sutharsan, Jin-Sung Park, Alan Mackay-Sim, Carolyn M. Sue
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2020-05-01
Saila:	Frontiers in Neuroscience
Gaiak:	hereditary spastic paraplegia SPAST axon transport peroxisomes axon degeneration epothilone D
Sarrera elektronikoa:	https://www.frontiersin.org/article/10.3389/fnins.2020.00401/full
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