Pharmacological rescue of mitochondrial and neuronal defects in SPG7 hereditary spastic paraplegia patient neurons using high throughput assays

SPG7 is the most common form of autosomal recessive hereditary spastic paraplegia (HSP). There is a lack of HSP-SPG7 human neuronal models to understand the disease mechanism and identify new drug treatments. We generated a human neuronal model of HSP-SPG7 using induced pluripotent stem (iPS) cell t...

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Auteurs principaux:	Gautam Wali, Yan Li, Erandhi Liyanage, Kishore R. Kumar, Margot L. Day, Carolyn M. Sue
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2023-09-01
Collection:	Frontiers in Neuroscience
Sujets:	hereditary spastic paraplegia (HSP) mitochondria induced pluripotent stem (iPS) cell cortical neurons high throughput imaging (HTI)
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fnins.2023.1231584/full
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