Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration

Abstract Alzheimer’s disease (AD) is characterized by the appearance of amyloid‐β plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the CK‐p25, 5XFAD, and Tau P301S mouse models of neurodegenerat...

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主要な著者:	Nader Morshed, William T Ralvenius, Alexi Nott, L Ashley Watson, Felicia H Rodriguez, Leyla A Akay, Brian A Joughin, Ping‐Chieh Pao, Jay Penney, Lauren LaRocque, Diego Mastroeni, Li‐Huei Tsai, Forest M White
フォーマット:	Artigo
言語:	Inglês
出版事項:	Springer Nature 2020-12-01
シリーズ:	Molecular Systems Biology
主題:	Alzheimer's disease microglia phosphoproteomics Siglec‐8 Siglec‐F
オンライン･アクセス:	https://doi.org/10.15252/msb.20209819
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