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Muscle very long-chain ceramides associate with insulin resistance independently of obesity

Lipids, in particular ceramides and diacylglycerols (DAGs), are implicated in insulin resistance (IR), however their precise roles remain unclear. Here, we leverage natural genetic variation to examine muscle lipids and systemic IR in 399 Diversity Outbred Australia mice fed either chow or a high-fa...

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Principais autores: Søren Madsen, Harry B. Cutler, Kristen C. Cooke, Meg Potter, Jasmine Khor, Christoph D. Rau, Stewart WC. Masson, Anna Howell, Zora Modrusan, Anthony S. Don, Jacqueline Stöckli, Alexis Diaz Vegas, David E. James
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-09-01
Colecção:Molecular Metabolism
Assuntos:
Insulin resistance
Skeletal muscle
Lipids
Ceramides
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S221287782500119X
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