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Genetic variance in the murine defensin locus modulates glucose homeostasis

Abstract Insulin resistance is a heritable risk factor for many chronic diseases; however, the genetic drivers remain elusive. In seeking these, we performed genetic mapping of insulin sensitivity in 670 chow-fed Diversity Outbred in Australia (DOz) mice and identified a genome-wide significant locu...

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Autori principali: Stewart W C Masson, Rebecca C Simpson, Harry B Cutler, Patrick W Carlos, Oana C Marian, Belinda Yau, Meg Potter, Søren Madsen, Kristen C Cooke, Niamh R Craw, Oliver K Fuller, Dylan J Harney, Mark Larance, Gregory J Cooney, Grant Morahan, Erin R Shanahan, Melkam A Kebede, Christopher Hodgkins, Richard J Payne, Jacqueline Stöckli, David E James
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Nature 2025-09-01
Serie:The EMBO Journal
Soggetti:
Insulin Sensitivity
Diversity Outbred
Microbiome
Defensin
Bile Acids
Accesso online:https://doi.org/10.1038/s44318-025-00555-5
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