Muscle very long-chain ceramides associate with insulin resistance independently of obesity

Lipids, in particular ceramides and diacylglycerols (DAGs), are implicated in insulin resistance (IR), however their precise roles remain unclear. Here, we leverage natural genetic variation to examine muscle lipids and systemic IR in 399 Diversity Outbred Australia mice fed either chow or a high-fa...

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Auteurs principaux:	Søren Madsen, Harry B. Cutler, Kristen C. Cooke, Meg Potter, Jasmine Khor, Christoph D. Rau, Stewart WC. Masson, Anna Howell, Zora Modrusan, Anthony S. Don, Jacqueline Stöckli, Alexis Diaz Vegas, David E. James
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2025-09-01
Collection:	Molecular Metabolism
Sujets:	Insulin resistance Skeletal muscle Lipids Ceramides
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S221287782500119X
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