TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments

The RNA binding protein TRBP is a component of the Dicer complex but its role in microRNA biogenesis remains poorly understood. Here the authors use a crowded RNA environment and single-molecule imaging to show that TRBP acts as a gatekeeper to prevent Dicer engagement with pre miRNA-like substrates...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Mohamed Fareh, Kyu-Hyeon Yeom, Anna C. Haagsma, Sweeny Chauhan, Inha Heo, Chirlmin Joo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2016-12-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/ncomms13694
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!