Model of ligand-triggered information transmission in G-protein coupled receptor complexes

We present a model for the effects of ligands on information transmission in G-Protein Coupled Receptor (GPCR) complexes. The model is built ab initio entirely on principles of statistical mechanics and tenets of information transmission theory and was validated in part using agonist-induced effecto...

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Hlavní autoři:	Roger D. Jones, Alan M. Jones
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-05-01
Edice:	Frontiers in Endocrinology
Témata:	G protein coupled receptor drug discovery information transmission maximum rate of entropy production transmembrane receptor barcode
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1111594/full
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