Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing

Summary: XIST RNA triggers chromosome-wide gene silencing and condenses an active chromosome into a Barr body. Here, we use inducible human XIST to examine early steps in the process, showing that XIST modifies cytoarchitecture before widespread gene silencing. In just 2–4 h, barely visible transcri...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Melvys Valledor, Meg Byron, Brett Dumas, Dawn M. Carone, Lisa L. Hall, Jeanne B. Lawrence
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2023-07-01
Sarja:	Cell Reports
Aiheet:	CP: Molecular biology CP: Stem cell research
Linkit:	http://www.sciencedirect.com/science/article/pii/S2211124723006976
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