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Distinct type of transmission barrier revealed by study of multiple prion determinants of Rnq1.

Prions are self-propagating protein conformations. Transmission of the prion state between non-identical proteins, e.g. between homologous proteins from different species, is frequently inefficient. Transmission barriers are attributed to sequence differences in prion proteins, but their underlying...

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Hlavní autoři: Michele L Kadnar, Gulnara Articov, Irina L Derkatch
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2010-01-01
Edice:PLoS Genetics
On-line přístup:http://europepmc.org/articles/PMC2809767?pdf=render
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