HLF and hTERT cooperatively enable partial immortalization of human hematopoietic stem and progenitor cells

Hematopoietic stem and progenitor cells (HSPCs), residing at the apex of the hematopoietic hierarchy, are critical for the generation of all blood and immune cell lineages. This unique capacity makes HSPCs indispensable for advancing cell and gene therapies aimed at correcting defects across hematop...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Manoj Kumar K. Azhagiri, Els Verhoeyen, Kumarasamypet Murugesan Mohankumar, Srujan Kumar Marepally, Vigneshwaran Venkatesan, Saravanabhavan Thangavel
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2026-01-01
Цуврал:	Frontiers in Bioengineering and Biotechnology
Нөхцлүүд:	Ex vivoHSPC culture hematopoietic stem and progenitor cells HLF immortalization primary cell-like models prolonged HSPCs culture, HSPCs immortalization
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fbioe.2025.1731355/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!